A novel prognostic model for transplant-free survival in primary sclerosing cholangitis.

ABSTRACT:

Objective

Most prognostic models for primary sclerosing cholangitis (PSC) are based on patients referred to tertiary care and may not be applicable for the majority of patients with PSC. The aim of this study was to construct and externally validate a novel, broadly applicable prognostic model for transplant-free survival in PSC, based on a large, predominantly population-based cohort using readily available variables.

Design

The derivation cohort consisted of 692 patients with PSC from the Netherlands, the validation cohort of 264 patients with PSC from the UK. Retrospectively, clinical and biochemical variables were collected. We derived the prognostic index from a multivariable Cox regression model in which predictors were selected and parameters were estimated using the

SUBMITTER: de Vries EM 

PROVIDER: S-EPMC6145288 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature