The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer's disease.

ABSTRACT:

Background

Misfolding of microtubule-associated protein tau (MAPT) within neurons into neurofibrillary tangles is an important pathological feature of Alzheimer's disease (AD). Tau pathology correlates with cognitive decline in AD and follows a stereotypical anatomical course; several recent studies indicate that tau pathology spreads inter-neuronally via misfolded tau "seeds." Previous research has focused on neurons as the source of these tau seeds. However, recent studies as well as the data contained herein suggest that microglia, the resident immune cells of the central nervous system, play a direct role in the spread of tau pathology.

Methods

Primary adult microglia were isolated from human AD cases and the rTg4510 tauopathy mouse model and used for analysis of gene ex

SUBMITTER: Hopp SC 

PROVIDER: S-EPMC6145371 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature