Particulate metal exposures induce plasma metabolome changes in a commuter panel study.

ABSTRACT:

Introduction

Advances in liquid chromatography-mass spectrometry (LC-MS) have enabled high-resolution metabolomics (HRM) to emerge as a sensitive tool for measuring environmental exposures and corresponding biological response. Using measurements collected as part of a large, panel-based study of car commuters, the current analysis examines in-vehicle air pollution concentrations, targeted inflammatory biomarker levels, and metabolomic profiles to trace potential metabolic perturbations associated with on-road traffic exposures.

Methods

A 60-person panel of adults participated in a crossover study, where each participant conducted a highway commute and randomized to either a side-street commute or clinic exposure session. In addition to in-vehicle exposure characterizations,

SUBMITTER: Ladva CN 

PROVIDER: S-EPMC6145583 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature