Autotaxin-β interaction with the cell surface via syndecan-4 impacts on cancer cell proliferation and metastasis.

ABSTRACT: Autotaxin (ATX) promotes cancer cell metastasis through the production of lysophosphatidic acid (LPA). ATX binds to αvβ3 integrins controlling metastasis of breast cancer cells. We screened a series of cancer cell lines derived from diverse human and mouse solid tumors for the capacity of binding to ATX and found only a modest correlation with their level of αvβ3 integrin expression. These results strongly suggested the existence of another cell surface ATX-interacting factor. Indeed, ATXα has been shown to bind heparan-sulfate chains because of its unique polybasic insertion sequence, although the biological significance is unknown. We demonstrated here, that among all cell surface heparan-sulfate proteoglycans, syndecan-4 (SDC4) was essential for cancer cell interaction with ATXβ but was

SUBMITTER: Leblanc R 

PROVIDER: S-EPMC6145688 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature