Association Between Adjuvant Chemotherapy and Overall Survival in Patients With Rectal Cancer and Pathological Complete Response After Neoadjuvant Chemotherapy and Resection.

ABSTRACT:

Importance

Although American guidelines recommend use of adjuvant chemotherapy in patients with locally advanced rectal cancer, individuals who achieve a pathological complete response (pCR) following neoadjuvant chemoradiotherapy are less likely to receive adjuvant treatment than incomplete responders. The association and resection of adjuvant chemotherapy with survival in patients with pCR is unclear.

Objective

To determine whether patients with locally advanced rectal cancer who achieve pCR after neoadjuvant chemoradiation therapy and resection benefit from the administration of adjuvant chemotherapy.

Design, setting, and participants

This retrospective propensity score-matched cohort study identified patients with locally advanced rectal cancer from the National C

SUBMITTER: Dossa F 

PROVIDER: S-EPMC6145724 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature