Assessment of a Noninvasive Exhaled Breath Test for the Diagnosis of Oesophagogastric Cancer.

ABSTRACT:

Importance

Early esophagogastric cancer (OGC) stage presents with nonspecific symptoms.

Objective

The aim of this study was to determine the accuracy of a breath test for the diagnosis of OGC in a multicenter validation study.

Design, setting, and participants

Patient recruitment for this diagnostic validation study was conducted at 3 London hospital sites, with breath samples returned to a central laboratory for selected ion flow tube mass spectrometry (SIFT-MS) analysis. Based on a 1:1 cancer:control ratio, and maintaining a sensitivity and specificity of 80%, the sample size required was 325 patients. All patients with cancer were on a curative treatment pathway, and patients were recruited consecutively. Among the 335 patients included; 172 were in the control gro

SUBMITTER: Markar SR 

PROVIDER: S-EPMC6145735 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature