Association of Smoking Status With Recurrence, Metastasis, and Mortality Among Patients With Localized Prostate Cancer Undergoing Prostatectomy or Radiotherapy: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Studies investigating the association of cigarette smoking with prostate cancer incidence and outcomes have revealed controversial results.

Objective

To systematically review and analyze the association of smoking status with biochemical recurrence, metastasis, and cancer-specific mortality among patients with localized prostate cancer undergoing primary radical prostatectomy or radiotherapy.

Data sources

A systematic search of original articles published between January 2000 and March 2017 was performed using PubMed, MEDLINE, Embase, and Cochrane Library databases in March 2017.

Study selection

Observational studies reporting Cox proportional hazards regression or logistic regression analyses were independently screened.

Data extraction and synth

SUBMITTER: Foerster B 

PROVIDER: S-EPMC6145736 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature