Association of Sickle Cell Trait With Ischemic Stroke Among African Americans: A Meta-analysis.

ABSTRACT:

Importance

African Americans and individuals of African ancestry have a higher risk of stroke compared with non-Hispanic white individuals. Identifying the source of this disparity could provide an opportunity for clinical stroke risk stratification and more targeted therapy. Whether sickle cell trait (SCT) is an indicator of increased risk of ischemic stroke among African Americans is still unclear.

Objective

To examine whether SCT is associated with a higher risk of incident ischemic stroke among African Americans.

Design, setting, and participants

This meta-analysis assessed the association of SCT with the risk of incident ischemic stroke. Four large, prospective, population-based studies with African American cohorts were assessed: Jackson Heart Study (September 1

SUBMITTER: Hyacinth HI 

PROVIDER: S-EPMC6145767 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature