Effect of Budesonide Added to Large-Volume, Low-pressure Saline Sinus Irrigation for Chronic Rhinosinusitis: A Randomized Clinical Trial.

ABSTRACT:

Importance

Recent studies suggest that budesonide added to saline nasal lavage can be an effective treatment for patients with chronic rhinosinusitis (CRS).

Objective

To evaluate the incremental effect of adding budesonide to large-volume, low-pressure saline sinus irrigation.

Design, setting, and participants

This double-blind, placebo-controlled, randomized clinical trial was conducted at a quaternary care academic medical center between January 1, 2016, and February 16, 2017. A total of 80 adult patients with CRS were enrolled; 74 completed baseline assessments; and 61 remained in the trial to complete all analyses. Data analysis was conducted from March 2017 to August 2017.

Interventions

All study participants were provided with a sinus rinse kit including

SUBMITTER: Tait S 

PROVIDER: S-EPMC6145785 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature