Nighttime light exposure enhances Rev-erbα-targeting microRNAs and contributes to hepatic steatosis.

ABSTRACT:

Objective

The exposure to artificial light at night (ALAN) disrupts the biological rhythms and has been associated with the development of metabolic syndrome. MicroRNAs (miRNAs) display a critical role in fine-tuning the circadian system and energy metabolism. In this study, we aimed to assess whether altered miRNAs expression in the liver underlies metabolic disorders caused by disrupted biological rhythms.

Results

We found that C3H/HePas mice exposed to ALAN developed obesity, and hepatic steatosis, which was paralleled by decreased expression of Rev-erbα and up-regulation of its lipogenic targets ACL and FAS in liver. Furthermore, the expression of Rev-erbα-targeting miRNAs, miR-140-5p, 185-5p, 326-5p and 328-5p were increased in this group. Consistently, overexpression o

SUBMITTER: Borck PC 

PROVIDER: S-EPMC6145802 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature