Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death.

ABSTRACT: The level of copy number alteration (CNA), termed CNA burden, in the tumor genome is associated with recurrence of primary prostate cancer. Whether CNA burden is associated with prostate cancer survival or outcomes in other cancers is unknown. We analyzed the CNA landscape of conservatively treated prostate cancer in a biopsy and transurethral resection cohort, reflecting an increasingly common treatment approach. We find that CNA burden is prognostic for cancer-specific death, independent of standard clinical prognosticators. More broadly, we find CNA burden is significantly associated with disease-free and overall survival in primary breast, endometrial, renal clear cell, thyroid, and colorectal cancer in TCGA cohorts. To assess clinical applicability, we validated these findings in an i

SUBMITTER: Hieronymus H 

PROVIDER: S-EPMC6145837 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature