MicroRNA-194-5p Levels Decrease during Deep Hypothermic Circulatory Arrest.

ABSTRACT: Hypothermia has been reported to be effective in protecting the brain in various clinical conditions, including resuscitation after cardiac arrest and complex cardiovascular surgery, and is considered to be a promising therapy for stroke. The present study aimed to confirm the pivotal role that miRNA-194-5p plays in deep hypothermia circulation arrest. On the basis of reductions in expression of miR-194-5p in the circulation of 21 aortic dissection patients who underwent deep hypothermia circulatory arrest, the specific expression, target, and function of miR-194-5p was investigated using primary neuron culture, polymerase chain reaction, in situ hybridization, and flow cytometry methods. Our results showed that miR-194-5p expression was significantly downregulated in hypothermia oxygen gl

SUBMITTER: Wang X 

PROVIDER: S-EPMC6145897 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature