Optogenetic Peripheral Nerve Immunogenicity.

ABSTRACT: Optogenetic technologies have been the subject of great excitement within the scientific community for their ability to demystify complex neurophysiological pathways in the central (CNS) and peripheral nervous systems (PNS). The excitement surrounding optogenetics has also extended to the clinic with a trial for ChR2 in the treatment of retinitis pigmentosa currently underway and additional trials anticipated for the near future. In this work, we identify the cause of loss-of-expression in response to transdermal illumination of an optogenetically active peroneal nerve following an anterior compartment (AC) injection of AAV6-hSyn-ChR2(H134R) with and without a fluorescent reporter. Using Sprague Dawley Rag2^-/- rats and appropriate controls, we discover optogenetic loss-of-expres

SUBMITTER: Maimon BE 

PROVIDER: S-EPMC6145901 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature