Stargazin Dephosphorylation Mediates Homeostatic Synaptic Downscaling of Excitatory Synapses.

ABSTRACT: Synaptic scaling is a form of homeostatic plasticity that is critical for maintaining neuronal activity within a dynamic range, and which alters synaptic strength through changes in postsynaptic AMPA-type glutamate receptors. Homeostatic scaling down of excitatory synapses has been shown to occur during sleep, and to contribute to synapse remodeling and memory consolidation, but the underlying mechanisms are only partially known. Here, we report that synaptic downscaling in cortical neurons is accompanied by dephosphorylation of the transmembrane AMPA receptor regulatory protein stargazin, and by an increase in its cell surface mobility. The changes in stargazin surface diffusion were paralleled by an increase in the mobility of GluA1-containing AMPA receptors at synaptic sites. In additio

SUBMITTER: Louros SR 

PROVIDER: S-EPMC6146028 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature