Improved ontology for eukaryotic single-exon coding sequences in biological databases.

ABSTRACT: Efficient extraction of knowledge from biological data requires the development of structured vocabularies to unambiguously define biological terms. This paper proposes descriptions and definitions to disambiguate the term 'single-exon gene'. Eukaryotic Single-Exon Genes (SEGs) have been defined as genes that do not have introns in their protein coding sequences. They have been studied not only to determine their origin and evolution but also because their expression has been linked to several types of human cancer and neurological/developmental disorders and many exhibit tissue-specific transcription. Unfortunately, the term 'SEGs' is rife with ambiguity, leading to biological misinterpretations. In the classic definition, no distinction is made between SEGs that harbor introns in their u

SUBMITTER: Jorquera R 

PROVIDER: S-EPMC6146118 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature