Porous Nanoparticles With Self-Adjuvanting M2e-Fusion Protein and Recombinant Hemagglutinin Provide Strong and Broadly Protective Immunity Against Influenza Virus Infections.

ABSTRACT: Due to the high risk of an outbreak of pandemic influenza, the development of a broadly protective universal influenza vaccine is highly warranted. The design of such a vaccine has attracted attention and much focus has been given to nanoparticle-based influenza vaccines which can be administered intranasally. This is particularly interesting since, contrary to injectable vaccines, mucosal vaccines elicit local IgA and lung resident T cell immunity, which have been found to correlate with stronger protection in experimental models of influenza virus infections. Also, studies in human volunteers have indicated that pre-existing CD4⁺ T cells correlate well to increased resistance against infection. We have previously developed a fusion protein with 3 copies of the ectodomain of ma

SUBMITTER: Bernasconi V 

PROVIDER: S-EPMC6146233 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature