Adverse effects of long-term weight gain on microvascular endothelial function.

ABSTRACT:

Background

Endothelial dysfunction is the first stage of the atherosclerotic cascade, and independently associated with cardiovascular events. We evaluated the associations of longitudinal changes in weight, waist circumference, body fat percentage and lean mass index with changes in endothelial function.

Methods

521 community-based subjects who belonged to hypertensive sibships and had no history of myocardial infarction or stroke had their anthropometric measures and endothelial function assessed a mean of 8.5 years apart. Endothelial function was assessed with brachial artery ultrasound, yielding measures of flow-mediated dilation and reactive hyperemia. We used multivariable linear regression with generalised estimating equations to assess the associations of longitudina

SUBMITTER: Coutinho T 

PROVIDER: S-EPMC6146400 | biostudies-literature | 2018 Sep - Oct

REPOSITORIES: biostudies-literature