Venous congestion and pulmonary vascular function in Fontan circulation: Implications for prognosis and treatment.

ABSTRACT:

Background

Elevation in central venous pressure (CVP) plays a fundamental pathophysiologic role in Fontan circulation. Because there is no sub-pulmonary ventricle in this system, CVP also provides the driving force for pulmonary blood flow. We hypothesized that this would make Fontan patients more susceptible to even low-level elevation in pulmonary vascular resistance index (PVRI), resulting in greater systemic venous congestion and adverse outcomes.

Methods

Adult Fontan patients and controls without congenital heart disease undergoing clinical evaluation that included cardiac catheterization and echocardiography were examined retrospectively. Outcomes including all-cause mortality and the development of Fontan associated diseases (FAD, defined as protein losing enteropathy

SUBMITTER: Egbe AC 

PROVIDER: S-EPMC6146405 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature