Waves of chromatin modifications in mouse dendritic cells in response to LPS stimulation.

ABSTRACT:

Background

The importance of transcription factors (TFs) and epigenetic modifications in the control of gene expression is widely accepted. However, causal relationships between changes in TF binding, histone modifications, and gene expression during the response to extracellular stimuli are not well understood. Here, we analyze the ordering of these events on a genome-wide scale in dendritic cells in response to lipopolysaccharide (LPS) stimulation.

Results

Using a ChIP-seq time series dataset, we find that the LPS-induced accumulation of different histone modifications follows clearly distinct patterns. Increases in H3K4me3 appear to coincide with transcriptional activation. In contrast, H3K9K14ac accumulates early after stimulation, and H3K36me3 at later time points. Inte

SUBMITTER: Vandenbon A 

PROVIDER: S-EPMC6146659 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature