Ancient Evolutionary Origin and Positive Selection of the Retroviral Restriction Factor <i>Fv1</i> in Muroid Rodents.

ABSTRACT: The laboratory mouse Fv1 gene encodes a retroviral restriction factor that mediates resistance to murine leukemia viruses (MLVs). Sequence similarity between Fv1 and the gag protein of the murine endogenous retrovirus L (MuERV-L) family of ERVs suggests that Fv1 was coopted from an ancient provirus. Previous evolutionary studies found Fv1 orthologs only in the genus Mus Here, we describe identification of orthologous Fv1 sequences in several species belonging to multiple families of rodents outside the genus Mus We show that these Fv1 orthologs are in the same region of conserved synteny, between the genes Miip and Mfn2, suggesting a minimum insertion time of 45 million years for the ancient progenitor of Fv1</

SUBMITTER: Boso G 

PROVIDER: S-EPMC6146698 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature