Transcranial focused ultrasound stimulation of motor cortical areas in freely-moving awake rats.

ABSTRACT:

Background

Low-intensity transcranial focused ultrasound (tFUS) has emerged as a new non-invasive modality of brain stimulation with the potential for high spatial selectivity and penetration depth. Anesthesia is typically applied in animal-based tFUS brain stimulation models; however, the type and depth of anesthesia are known to introduce variability in responsiveness to the stimulation. Therefore, the ability to conduct sonication experiments on awake small animals, such as rats, is warranted to avoid confounding effects of anesthesia.

Results

We developed a miniature tFUS headgear, operating at 600 kHz, which can be attached to the skull of Sprague-Dawley rats through an implanted pedestal, allowing the ultrasound to be transcranially delivered to motor cortical areas of

SUBMITTER: Lee W 

PROVIDER: S-EPMC6146769 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature