Biocompatible glyconanomaterials based on HPMA-copolymer for specific targeting of galectin-3.

ABSTRACT:

Background

Galectin-3 (Gal-3) is a promising target in cancer therapy with a high therapeutic potential due to its abundant localization within the tumor tissue and its involvement in tumor development and proliferation. Potential clinical application of Gal-3-targeted inhibitors is often complicated by their insufficient selectivity or low biocompatibility. Nanomaterials based on N-(2-hydroxypropyl)methacrylamide (HPMA) nanocarrier are attractive for in vivo application due to their good water solubility and lack of toxicity and immunogenicity. Their conjugation with tailored carbohydrate ligands can yield specific glyconanomaterials applicable for targeting biomedicinally relevant lectins like Gal-3.

Results

In the present study we describe the synthesis and the structure-

SUBMITTER: Bojarova P 

PROVIDER: S-EPMC6146777 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature