Analysis of porcine body size variation using re-sequencing data of miniature and large pigs.

ABSTRACT:

Background

Domestication has led to substantial phenotypic and genetic variation in domestic animals. In pigs, the size of so called minipigs differs by one order of magnitude compared to breeds of large body size. We used biallelic SNPs identified from re-sequencing data to compare various publicly available wild and domestic populations against two minipig breeds to gain better understanding of the genetic background of the extensive body size variation. We combined two complementary measures, expected heterozygosity and the composite likelihood ratio test implemented in "SweepFinder", to identify signatures of selection in Minipigs. We intersected these sweep regions with a measure of differentiation, namely F_ST, to remove regions of low variation across pigs. An extr

SUBMITTER: Reimer C 

PROVIDER: S-EPMC6146782 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature