Antiretroviral drug use and HIV drug resistance among MSM and transgender women in sub-Saharan Africa.

ABSTRACT:

Objective

To analyze antiretroviral drug use and HIV drug resistance among HIV-infected MSM and transgender women who were screened for participation in the HIV Prevention Trials Network 075 study.

Methods

A qualitative assay was used to detect 20 antiretroviral drugs in five drug classes; this assay is based on liquid chromatography coupled with high-resolution accurate-mass mass spectrometry. HIV viral load testing was performed using the RealTime HIV-1 Viral Load Assay. HIV drug resistance testing was performed using the ViroSeq HIV-1 Genotyping System. Logistic regression was used to evaluate factors associated with study outcomes.

Results

Antiretroviral drugs were detected in 63 (34.4%) of 183 participants who had confirmed HIV infection at screening; 11 (17.5%)

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6146920 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature