Deletion of the microtubule-associated protein 6 (MAP6) results in skeletal muscle dysfunction.

ABSTRACT:

Background

The skeletal muscle fiber has a specific and precise intracellular organization which is at the basis of an efficient muscle contraction. Microtubules are long known to play a major role in the function and organization of many cells, but in skeletal muscle, the contribution of the microtubule cytoskeleton to the efficiency of contraction has only recently been studied. The microtubule network is dynamic and is regulated by many microtubule-associated proteins (MAPs). In the present study, the role of the MAP6 protein in skeletal muscle organization and function has been studied using the MAP6 knockout mouse line.

Methods

The presence of MAP6 transcripts and proteins was shown in mouse muscle homogenates and primary culture using RT-PCR and western blot. The in vi

SUBMITTER: Sebastien M 

PROVIDER: S-EPMC6147105 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature