Computational identification and analysis of neurodegenerative disease associated protein kinases in hominid genomes.

ABSTRACT: Protein kinases play an important role in the incidence of neurodegenerative diseases. However their incidence in non-human primates is found to be very low. Small differences among the genomes might influence the disease susceptibilities. The present study deals with finding the genetic differences of protein kinases in humans and their three closest evolutionary partners chimpanzee, gorilla and orangutan for three neurodegenerative diseases namely, Alzheimer's, Parkinson's and Huntington's diseases. In total 47 human protein kinases associated with three neurodegenerative diseases and their orthologs from other three non-human primates were identified and analyzed for any possible susceptibility factors in humans. Multiple sequence alignment and pairwise sequence alignment revealed that,

SUBMITTER: Jayapalan S 

PROVIDER: S-EPMC6147167 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature