Comparison of fluticasone propionate and budesonide on COPD macrophage and neutrophil function.

ABSTRACT:

Background

Inhaled corticosteroid use is associated with increased rates of pneumonia in COPD patients. The underlying mechanism is unknown, although recent data suggest that pneumonia is more frequent in patients treated with fluticasone propionate (FP) than budesonide. Macrophages and neutrophils from COPD patients are deficient in clearing bacteria, and this might explain increased bacterial colonization in COPD. Inhaled corticosteroid may further suppress this response; therefore, we examined the effect of FP and budesonide on phagocytosis of common respiratory pathogens by monocyte-derived macrophages (MDMs) and neutrophils.

Methods

MDMs from COPD patients (n=20-24) were preincubated with FP or budesonide for 1 or 18 hours, after which phagocytosis of fluorescently labe

SUBMITTER: Belchamber KB 

PROVIDER: S-EPMC6147211 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature