Combination therapy for treatment of Pseudomonas aeruginosa bloodstream infections.

ABSTRACT:

Objectives

Management of bloodstream infections ("BSIs") caused by Pseudomonas aeruginosa remains controversial as data supporting the use of definite combination treatment for severe P. aeruginosa infections remain conflicting. We aimed to determine differences in mortality between patients treated with definite combination therapy and monotherapy in a large 11-year cohort.

Methods

All consecutive patients with P. aeruginosa BSI hospitalized at the University Hospital Basel, Switzerland, a tertiary academic care center, from January 2003 to December 2013 were included. Pertinent clinical data was assessed. Patients with and without definite combination therapy were compared and hazard ratios for death were calculated.

Results

During the study period, 187 patients wit

SUBMITTER: Tschudin-Sutter S 

PROVIDER: S-EPMC6147480 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature