Molecular assays for antimalarial drug resistance surveillance: A target product profile.

ABSTRACT: Antimalarial drug resistance is a major constraint for malaria control and elimination efforts. Artemisinin-based combination therapy is now the mainstay for malaria treatment. However, delayed parasite clearance following treatment with artemisinin derivatives has now spread in the Greater Mekong Sub region and may emerge or spread to other malaria endemic regions. This spread is of great concern for malaria control programmes, as no alternatives to artemisinin-based combination therapies are expected to be available in the near future. There is a need to strengthen surveillance systems for early detection and response to the antimalarial drug resistance threat. Current surveillance is mainly done through therapeutic efficacy studies; however these studies are complex and both time- and r

SUBMITTER: Nsanzabana C 

PROVIDER: S-EPMC6147503 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature