In silico analysis of the Mus musculus uterine gene expression landscape during pregnancy identifies putative upstream regulators for labour.

ABSTRACT:

Background

The molecular pathways involved in the transition from uterine quiescence to overt labour are mapped and form the currently established pharmacological targets for both the induction and inhibition of human labour. However, both spontaneous premature labour and functional dystocia occur and are difficult to treat adequately. The identification of upstream regulators involved in the onset and orchestration of labour pathways is essential to develop additional therapies that will contribute to the regulation of the timing of birth.

Objectives

To define uterine biological processes and their upstream activators involved in the transition from uterine quiescence to overt labour.

Study design

The uterus of non-pregnant and pregnant FVB M. musculus is collected a

SUBMITTER: Fernando F 

PROVIDER: S-EPMC6147639 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature