Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina.

ABSTRACT: Increasing evidence suggests that dysregulation of lipid metabolism is associated with neurodegeneration in retinal diseases such as age-related macular degeneration and in brain disorders such as Alzheimer's and Parkinson's diseases. Lipid storage organelles (lipid droplets, LDs), accumulate in many cell types in response to stress, and it is now clear that LDs function not only as lipid stores but also as dynamic regulators of the stress response. However, whether these LDs are always protective or can also be deleterious to the cell is unknown. Here, we investigated the consequences of LD accumulation on retinal cell homeostasis under physiological and stress conditions in Drosophila and in mice. In wild-type Drosophila, we show that dFatp is required and sufficient for expansion of LD

SUBMITTER: Van Den Brink DM 

PROVIDER: S-EPMC6147681 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature