Helioscopianoids A-Q, bioactive jatrophane diterpenoid esters from Euphorbia helioscopia.

ABSTRACT: The EtOH extracts of the whole plants of Euphorbia helioscopia afforded 17 new jatrophane diterpenoid esters, helioscopianoids A-Q (1-17), along with eight known compounds (18-25). Their structures were elucidated by extensive spectroscopic methods and Mo₂(OAc)₄-induced ECD analysis, and the structures of compounds 1, 2, and 7 were confirmed by X-ray crystallography. Compounds 1-17 were evaluated for inhibitory effects on P-glycoprotein (P-gp) in an adriamycin (ADM)-resistant human breast adenocarcinoma cell line (MCF-7/ADR) and neuroprotective effects against serum deprivation-induced and rotenone-induced PC12 cell damage. Compounds 8 and 16 increased the accumulation of ADM in MCF-7/

SUBMITTER: Mai Z 

PROVIDER: S-EPMC6147808 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature