Development of macrolide resistance in Bordetella bronchiseptica is associated with the loss of virulence.

ABSTRACT:

Background

Why resistance to specific antibiotics emerges and spreads rapidly in some bacteria confronting these drugs but not others remains a mystery. Resistance to erythromycin in the respiratory pathogens Staphylococcus aureus and Streptococcus pneumoniae emerged rapidly and increased problematically. However, resistance is uncommon amongst the classic Bordetella species despite infections being treated with this macrolide for decades.

Objectives

We examined whether the apparent progenitor of the classic Bordetella spp., Bordetella bronchiseptica, is able to rapidly generate de novo resistance to antibiotics and, if so, why such resistance might not persist and propagate.

Methods

Independent strains of B. bronchiseptica resistant to erythromycin were generated in

SUBMITTER: Dewan KK 

PROVIDER: S-EPMC6148206 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature