Prenatal exposure to TiO₂ nanoparticles in mice causes behavioral deficits with relevance to autism spectrum disorder and beyond.

ABSTRACT: Environmental factors are involved in the etiology of autism spectrum disorder (ASD) and may contribute to the raise in its incidence rate. It is currently unknown whether the increasing use of nanoparticles such as titanium dioxide (TiO₂ NPs) in consumer products and biomedical applications may play a role in these associations. While nano-sized TiO₂ is generally regarded as safe and non-toxic, excessive exposure to TiO₂ NPs may be associated with negative health consequences especially when occurring during sensitive developmental periods. To test if prenatal exposure to TiO₂ NPs alters fetal development and behavioral functions relevant to ASD, C57Bl6/N dams were subjected to a single intravenous injection of a low (100 µg) or high (1000 µg) d

SUBMITTER: Notter T 

PROVIDER: S-EPMC6148221 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature