Intrinsic mitral valve alterations in hypertrophic cardiomyopathy sarcomere mutation carriers.

ABSTRACT:

Aims

Mitral valve (MV) abnormalities are recognized features of hypertrophic cardiomyopathy (HCM), and there is preliminary evidence suggesting they are intrinsic phenotypic manifestations of sarcomere mutations, present in mutation carriers without left ventricular (LV) hypertrophy (subclinical HCM). However, further study is required to characterize the nature of these changes and their functional impact. Thus, we performed comprehensive echocardiographic analysis of MV structure and function on a genotyped population.

Methods and results

MV and papillary muscle echocardiographic parameters were measured in 192 genotyped individuals, including 50 overt HCM, 79 subclinical HCM, and 63 mutation-negative, healthy relatives as normal controls. Compared to controls, subclinical

SUBMITTER: Groarke JD 

PROVIDER: S-EPMC6148328 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature