A fluid-to-solid jamming transition underlies vertebrate body axis elongation.

ABSTRACT: Just as in clay moulding or glass blowing, physically sculpting biological structures requires the constituent material to locally flow like a fluid while maintaining overall mechanical integrity like a solid. Disordered soft materials, such as foams, emulsions and colloidal suspensions, switch from fluid-like to solid-like behaviours at a jamming transition^1-4. Similarly, cell collectives have been shown to display glassy dynamics in 2D and 3D^5,6 and jamming in cultured epithelial monolayers^7,8, behaviours recently predicted theoretically^9-11 and proposed to influence asthma pathobiology⁸ and tumour progression¹². However, little is known about whether these seemingly universal behaviours occur in vivo¹³ and, spe

SUBMITTER: Mongera A 

PROVIDER: S-EPMC6148385 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature