Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell development.

ABSTRACT: Notch1 signaling must elevate to high levels in order to drive the proliferation of CD4^-CD8^- double-negative (DN) thymocytes and progression to the CD4⁺CD8⁺ double-positive (DP) stage through β-selection. During this critical phase of pre-T-cell development, which is also known as the DN-DP transition, it is unclear whether the Notch1 transcriptional complex strengthens its signal output as a discrete unit or through cofactors. We previously showed that the protein inhibitor of activated STAT-like coactivator Zmiz1 is a context-dependent cofactor of Notch1 in T-cell leukemia. We also showed that withdrawal of Zmiz1 generated an early T-lineage progenitor (ETP) defect. Here, we show that this early defect seems inconsistent with loss-of-Notch1 fun

SUBMITTER: Wang Q 

PROVIDER: S-EPMC6148450 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature