Association of human leukocyte antigen DRB1 with anti-cyclic citrullinated peptide autoantibodies in Saudi patients with rheumatoid arthritis.

ABSTRACT:

Background

The genetic association between human leukocyte antigen (HLA)-DRB1 alleles and the risk of development of autoantibodies has been investigated, but there are few studies from the Gulf region.

Objectives

To investigate the association between the HLA-DRB1 shared epitope and the risk for development of autoantibodies in rheumatoid arthritis (RA) patients in a Saudi population.

Design

Analytical cross-sectional study.

Setting

Tertiary care hospital in Riyadh, Saudi Arabia.

Patients and methods

We enrolled consecutive Saudi RA patients attending the rheumatology clinic between January and April 2015. Previously published data on HLA typing on unmatched healthy controls were used for comparison. HLA typing was performed using sequence-specific olig

SUBMITTER: Alrogy A 

PROVIDER: S-EPMC6148974 | biostudies-literature | 2017 Jan-Feb

REPOSITORIES: biostudies-literature