Proteinase 3; a potential target in chronic obstructive pulmonary disease and other chronic inflammatory diseases.

ABSTRACT: Chronic Obstructive Pulmonary Disease (COPD) is a common, multifactorial lung disease which results in significant impairment of patients' health and a large impact on society and health care burden. It is believed to be the result of prolonged, destructive neutrophilic inflammation which results in progressive damage to lung structures. During this process, large quantities of neutrophil serine proteinases (NSPs) are released which initiate the damage and contribute towards driving a persistent inflammatory state.Neutrophil elastase has long been considered the key NSP involved in the pathophysiology of COPD. However, in recent years, a significant role for Proteinase 3 (PR3) in disease development has emerged, both in COPD and other chronic inflammatory conditions. Therefore, there is a

SUBMITTER: Crisford H 

PROVIDER: S-EPMC6149181 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature