Health-related quality of life impact of minor and major bleeding events during dual antiplatelet therapy: a systematic literature review and patient preference elicitation study.

ABSTRACT:

Background

Dual antiplatelet therapy (DAPT) is the recommended preventative treatment for secondary ischaemic events, but increases the risk of bleeding, potentially affecting patients' health-related quality-of-life (HRQoL). Varied utility decrements have been used in cost-effectiveness models assessing alternative DAPT regimens, but it is unclear which of these decrements are most appropriate. Therefore, we reviewed existing sources of utility decrements for bleeds in patients receiving DAPT and undertook primary research to estimate utility decrements through a patient elicitation exercise using vignettes and the EuroQol EQ-5D.

Methods

MEDLINE, PubMed and references of included studies were searched. Primary research and decision analytic modelling studies reporting utili

SUBMITTER: Doble B 

PROVIDER: S-EPMC6149200 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature