Thin Lamina Cribrosa Beams Have Different Collagen Microstructure Than Thick Beams.

ABSTRACT:

Purpose

To compare the collagen microstructural crimp characteristics between thin and thick lamina cribrosa (LC) beams.

Methods

Seven eyes from four sheep were fixed at 5 mm Hg IOP in 10% formalin. For each eye, one to three coronal cryosections through the LC were imaged with polarized light microscopy and analyzed to visualize the LC and determine collagen fiber microstructure. For every beam, we measured its width and three characteristics of the crimp of its collagen fibers: waviness, tortuosity, and amplitude. Linear mixed effects models were used to test whether crimp characteristics were associated with the LC beam width.

Results

For each eye and over all the eyes, LC beam width was positively associated with crimp waviness and tortuosity, and negatively assoc

SUBMITTER: Brazile BL 

PROVIDER: S-EPMC6149225 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature