The effects of ultrasound exposure on P-glycoprotein-mediated multidrug resistance in vitro and in vivo.

ABSTRACT:

Background

Multidrug resistance (MDR) is often responsible for the failure of chemotherapy treatment, and current strategies for cancer MDR are not adequately satisfying as to their efficacy and safety. In this study, we sought to determine the anti-MDR effects of ultrasound (US) irradiation and its underlying mechanisms against drug-resistance.

Methods

MDR variant MCF-7/ADR cell lines and endothelial cell lines were used to determine the appropriate ultrasound intensity for in vitro experiments. MCF-7/ADR cell and HEPG2/ADM cells were used to assess the anti-MDR effect of US irradiation. Intracellular adriamycin (ADM) accumulation, Cell viability, cell proliferation and cell apoptosis were evaluated after ADM + US treatment or ADM treatment alone. MCF-7/ADR xenograft mice w

SUBMITTER: Huang C 

PROVIDER: S-EPMC6149229 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature