Study on the Anticoagulant or Procoagulant Activities of Type II Phenolic Acid Derivatives.

ABSTRACT: In this study, three type II phenolic acids (caffeic acid, p-hydroxycinnamic acid, and ferulic acid) were used to synthesize a total of 18 phenolic acid derivatives. With molecular docking for molecule design and target protein (factors) screening, in combination with the confirmation of target proteins (factors) by surface plasmon resonance, and the evaluation of haemostatic and anticoagulant activities with five blood assays (plasma recalcification time, prothrombin time, activated partial thromboplastin time, fibrinogen, and thrombin time), the data indicated that caffeic acid derivatives showed certain anticoagulant or procoagulant activities and that two other series contained compounds with the best anticoagulant activities. Using Materials Studio analysis, particular function

SUBMITTER: Luo X 

PROVIDER: S-EPMC6149684 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature