Synthesis and Anticandidal Activity Evaluation of New Benzimidazole-Thiazole Derivatives.

ABSTRACT: Azole-based antifungal agents constitute one of the important classes of antifungal drugs. Hence, in the present work, 12 new benzimidazole-thiazole derivatives 3a-3l were synthesized to evaluate their anticandidal activity against C.albicans, C.glabrata, C.krusei, and C.parapsilopsis. The structures of the newly synthesized compounds 3a-3l were confirmed by IR, ¹H-NMR, ¹³C-NMR, and ESI-MS spectroscopic methods. ADME parameters of synthesized compounds 3a-3l were predicted by an in-slico study and it was determined that all synthesized compounds may have a good pharmacokinetic profile. In the anticandidal activity studies, compounds 3c and 3d were found t

SUBMITTER: Kaplancıklı ZA 

PROVIDER: S-EPMC6149685 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature