Design and Synthesis of New Benzothiazole Compounds as Selective hMAO-B Inhibitors.

ABSTRACT: In the current work a new class of novel benzothiazole-hydrazone derivatives was designed and synthesized as hMAO-B inhibitors. Structures of the obtained compounds (3a-3j) were characterized by IR, ¹H-NMR, ¹³C-NMR, and HRMS spectroscopic methods. The inhibitory activity of compounds (3a-3j) against hMAO-A and hMAO-B enzymes was evaluated by using an in vitro fluorometric method. According to activity results, some of the synthesized compounds displayed selective and significant hMAO-B enzyme inhibitor activity. Compound 3e was the most active derivative in the series with an IC₅₀ value of 0.060 µM. Furthermore, cytotoxicity of compound 3e was investigated and found to be non-cytotoxic. Absorption,

SUBMITTER: Ilgın S 

PROVIDER: S-EPMC6149824 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature