Lipoprotein (a): a promising prognostic biomarker in patients with hepatocellular carcinoma after curative resection.

ABSTRACT:

Purpose

This study aimed to explore serum lipoprotein (a) (Lp(a)) levels and investigate their prognostic value in hepatocellular carcinoma (HCC) patients after curative resection.

Materials and methods

One cohort of 102 healthy individuals, one cohort of 172 HCC patients, and one cohort of 171 HCC patients undergoing curative resection were studied to evaluate serum Lp(a) levels and their prognostic significance, using Kaplan-Meier curves and log-rank tests.

Results

The Lp(a) levels in HCC patients were significantly lower than those in healthy individuals. Furthermore, the levels in HCC patients were significantly associated with recurrence. HCC patients were stratified into high Lp(a) (>20 mg/L) and low Lp(a) (≤20 mg/L) groups, using an optimal cutoff point for the

SUBMITTER: Gao XH 

PROVIDER: S-EPMC6149830 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature