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Chemical Constituents from Euphorbia kansui.

ABSTRACT: In this research, a new triterpenoid, tirucalla-8,24-diene-3?,11?-diol-7-one (1), and eupha-8,24-diene-3?,11?-diol-7-one (2), which was isolated from Euphorbia kansui for the first time, together with twelve other known compounds (3-14), were isolated from the ethyl acetate extract of Euphorbia kansui. Their structures were elucidated based on High resolution electrospray ionization mass spectrometry (HR-ESI-MS), Infrared Spectroscopy (IR), 1D and 2D Nuclear Magnetic Resonance (NMR) data. Both constituents 1 and 2 exhibited moderate cytotoxicity against colon cancer HCT-116, gastric cancer MKN-45 and breast cancer MCF-7.

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC6150036 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Chemical Constituents from Euphorbia kansui.

Zhang Qiao Q   Zhou Qin-Rong QR   Lou Jian-Wei JW   Chen Pei-Dong PD   Yao Wei-Feng WF   Tao Wei-Wei WW   Tang Yu-Ping YP   Dai Guan-Cheng GC   Wang Kun K   Zhang Li L  

Molecules (Basel, Switzerland) 20171208 12

In this research, a new triterpenoid, tirucalla-8,24-diene-3β,11β-diol-7-one (<b>1</b>), and eupha-8,24-diene-3β,11β-diol-7-one (<b>2</b>), which was isolated from <i>Euphorbia kansui</i> for the first time, together with twelve other known compounds (<b>3</b>-<b>14</b>), were isolated from the ethyl acetate extract of <i>Euphorbia kansui</i>. Their structures were elucidated based on High resolution electrospray ionization mass spectrometry (HR-ESI-MS), Infrared Spectroscopy (IR), 1D and 2D Nuc  ...[more]

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