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Clostridium novyi-NT in cancer therapy.

ABSTRACT: The attenuated anaerobic bacterium Clostridium novyi-NT (C. novyi-NT) is known for its ability to precisely germinate in and eradicate treatment-resistant hypoxic tumors in various experimental animal models and spontaneously occurring canine sarcomas. In this article, we review the therapeutic and toxicologic aspects of C. novyi-NT therapy, key challenges and limitations, and promising strategies to optimize its performance via recombinant DNA technology and immunotherapeutic approaches, to establish C. novyi-NT as an essential tool in cancer therapy.

SUBMITTER: Staedtke V 

PROVIDER: S-EPMC6150096 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature

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<i>Clostridium novyi</i>-NT in cancer therapy.

Staedtke Verena V   Roberts Nicholas J NJ   Bai Ren-Yuan RY   Zhou Shibin S  

Genes & diseases 20160206 2

The attenuated anaerobic bacterium <i>Clostridium novyi</i>-NT (<i>C. novyi</i>-NT) is known for its ability to precisely germinate in and eradicate treatment-resistant hypoxic tumors in various experimental animal models and spontaneously occurring canine sarcomas. In this article, we review the therapeutic and toxicologic aspects of <i>C. novyi</i>-NT therapy, key challenges and limitations, and promising strategies to optimize its performance <i>via</i> recombinant DNA technology and immunoth  ...[more]

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