New Adducts of Iriflophene and Flavonoids Isolated from Sedum aizoon L. with Potential Antitumor Activity.
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ABSTRACT:
SUBMITTER: Li M
PROVIDER: S-EPMC6150161 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
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New Adducts of Iriflophene and Flavonoids Isolated from Sedum aizoon L. with Potential Antitumor Activity.
Li Mingxiao M Qi Zheyuan Z Hao Yimeng Y Lv Chongning C Jia Lingyun L Wang Jing J Lu Jincai J
Molecules (Basel, Switzerland) 20171102 11
Four new special compounds with character of an iriflophene unit and a flavonoid unit connecting via a furan ring were isolated from the roots of <i>Sedum aizoon</i> L. Their corresponding structures were elucidated on the basis of spectroscopic analysis. The in vitro anti-proliferative activities against BXPC-3, A549, and MCF-7 tumor cell lines were evaluated. Compounds <b>3</b> and <b>4</b> exhibited moderate cytotoxic activities with IC<sub>50</sub> ranging from 24.84 to 37.22 μmol L<sup>-1</ ...[more]
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