Synthesis of Oxadiazole-Thiadiazole Hybrids and Their Anticandidal Activity.

ABSTRACT: In the field of infection management, it is a major challenge to discover a potent and safe antifungal agent due to the emergence of resistant strains. Hence, the goal of this paper is to design and synthesize novel oxadiazole-thiadiazole hybrid compounds (6a-6s) and evaluate their antifungal activity. The structures of synthesized compounds were elucidated by various methods including FT-IR, ¹H-NMR, ¹³C-NMR and HR-MS spectral data. Compounds were tested against four Candida species by broth microdilution assay. Compounds 6e, 6k and 6r, bearing a nitro group, showed significant antifungal activity against all fungi with minimum inhibitory concentration (MIC) in the range of 0.78-3.12 µg/mL. These compounds were also screened for their in

SUBMITTER: Levent S 

PROVIDER: S-EPMC6150172 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature